Emer Prof Allen Rodgers
My research focuses on the physicochemical and biochemical risk factors associated with the formation of kidney stones. This research area lends itself very well to laboratory investigation because the fundamental laws of physical chemistry pertaining to solubility, saturation, supersaturation, chemical kinetics, chemical equilibrium, precipitation and crystallization, are appropriate. As such, basic research involving the application of these concepts in crystallization processes in urine is necessary to gain insights into the physicochemical factors which influence stone initiation and growth, and to provide direction for the development of treatment protocols. However, the complexity of the medium in which these processes occur – urine – makes the problem scientifically challenging.
Allied to this basic science approach, my research investigates conservative dietary and supplemental interventions for reducing the risk of stone development. Nutrients and supplements of interest are polyunsaturated fatty acids, phytate, mineral waters, pomegranate, green teas, vitamin E, and traditional herbal dietary agents and stone medications (South Africa, China)
In South Africa, a unique situation exists with respect to this disease. Although it occurs in the white population to the same extent as elsewhere in western societies, stone formation in the black population is rare. Investigation of this phenomenon is another research focus of mine.
- Theka T, Rodgers A, Lewandowski L, Webber D, Allie-Hamdulay S. Effects of vitamin E ingestion on plasma and urinary risk factors for calcium oxalate urolithiasis in two population groups having different stone-risk profiles: evidence of different physiological handling mechanisms. JUrol Res 2012, 40:113-120
- Rodgers A. Race, ethnicity, and urolithiasis: a critical review. Urol Res 2013, 41:99-103
- Rodgers A, Allie-Hamdulay S, Jackson G, Durbach I. Theoretical modeling of the urinary supersaturation of calcium salts in healthy individuals and kidney stone patients: Precursors, speciation and therapeutic protocols for decreasing its value. J Cryst Growth 2013, 382:330-333
- Rodgers A. Urinary saturation: Casual or causal risk factor in urolithiasis. BJU International 2014, 114:104-110
- Rodgers A, Webber D, de Charmoy R, Jackson G, Ravenscroft N. Malic acid supplementation increases urinary citrate excretion and urinary pH: implications for the potential treatment of calcium oxalate stone disease. J Endourol 2014, 28:229-236
- Rodgers A, Webber D, Ramsout R, Gohel MD. Folium pyrrosiae ingestion has no effect on the thermodynamic or kinetic risk factors for calcium oxalate urolithiasis in healthy subjects: a poor prognosis for alternative treatment in stone formers. UROLITHIASIS 2015, 43:21-27